E-ISSN 2683-5961 | ISSN 2354-1814
 

Review Article

Online Publishing Date:
29 / 11 / 2022

 


Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review

Hassan Sani, Halimatu Sadiya Abdullahi, Sulaiman Abdullahi Barau.


Abstract
Covid-19, a global pandemic that has claimed over 2,900,000 deaths since its appearance in late 2019. It is caused by the virus SARS-CoV2, the result of the viral infection is an over reactive immunologic response by the innate and adaptive immunity. In severe Covi-19 patients the transition to ARDS is primarily due to cytokine storm, which is characterized by excessive inflammatory response and elevated serum levels of ferritin and pro-inflammatory cytokines, infiltration of neutrophils and monocytes into the lung; and reduced viral inhibiting cytokines, all of which contributes to the severity of the disease and causing death. The focus of this review is on collation of medicinal plants with strong anti-inflammatory activities which could be used alone or synergistically for enhanced therapeutic effect to cushion cytokine storm damaging effects. The plants collated evidently shows strong anti-inflammatory effects in vitro and in vivo via suppression of IL-1α, IL-1β, IL-6, IL-8, TNF-α, IFN-γ, monocyte chemoattractant protein-1 (MCP-1), and nuclear factor kappa B (NF-κB) expression, in addition to inhibiting cyclooxygenase I and II (COX I and II), and inducible nitric oxide synthase (iNOS) activity. The medicinal plants collated in this review could be used alone or synergistically in the future in clinics for enhanced therapeutic effect to cushion cytokine storm damaging effects. Isolation of the active principle and studies of the specific mechanism of action of the plants could be the objective of future research.

Key words: COVID-19, Cytokine storm, anti-inflammatory, plants, herbs, traditional medicine


 
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How to Cite this Article
Pubmed Style

Sani H, Abdullahi HS, Barau SA. Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review. Equijost. 2021; 8(2): 48-54. doi:https//dx.doi.org/10.4314/equijost.v8i2.9


Web Style

Sani H, Abdullahi HS, Barau SA. Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review. https://www.equijost.com/?mno=87699 [Access: March 04, 2024]. doi:https//dx.doi.org/10.4314/equijost.v8i2.9


AMA (American Medical Association) Style

Sani H, Abdullahi HS, Barau SA. Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review. Equijost. 2021; 8(2): 48-54. doi:https//dx.doi.org/10.4314/equijost.v8i2.9



Vancouver/ICMJE Style

Sani H, Abdullahi HS, Barau SA. Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review. Equijost. (2021), [cited March 04, 2024]; 8(2): 48-54. doi:https//dx.doi.org/10.4314/equijost.v8i2.9



Harvard Style

Sani, H., Abdullahi, . H. S. & Barau, . S. A. (2021) Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review. Equijost, 8 (2), 48-54. doi:https//dx.doi.org/10.4314/equijost.v8i2.9



Turabian Style

Sani, Hassan, Halimatu Sadiya Abdullahi, and Sulaiman Abdullahi Barau. 2021. Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review. Equity Journal of Science and Technology, 8 (2), 48-54. doi:https//dx.doi.org/10.4314/equijost.v8i2.9



Chicago Style

Sani, Hassan, Halimatu Sadiya Abdullahi, and Sulaiman Abdullahi Barau. "Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review." Equity Journal of Science and Technology 8 (2021), 48-54. doi:https//dx.doi.org/10.4314/equijost.v8i2.9



MLA (The Modern Language Association) Style

Sani, Hassan, Halimatu Sadiya Abdullahi, and Sulaiman Abdullahi Barau. "Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review." Equity Journal of Science and Technology 8.2 (2021), 48-54. Print. doi:https//dx.doi.org/10.4314/equijost.v8i2.9



APA (American Psychological Association) Style

Sani, H., Abdullahi, . H. S. & Barau, . S. A. (2021) Some Medicinal Plants with Ameliorative Potentials on COVID-19 Cytokine Storm: A Review. Equity Journal of Science and Technology, 8 (2), 48-54. doi:https//dx.doi.org/10.4314/equijost.v8i2.9





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