Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats

Joseph Olugbenga Soola; Wasiu Eniola Olooto; Ifabunmi Oduyemi Osonuga; Olusoji Adebusoye Oyesola; Adetola Adebayo Amballi; Hammed Adedeji Adenusi; Monisola Abosede Ayodele

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Research Article
Online Published: 17 Oct 2024

Equijost. 2024; 11(1): 74-80

Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats

Joseph Olugbenga Soola, Wasiu Eniola Olooto, Ifabunmi Oduyemi Osonuga, Olusoji Adebusoye Oyesola, Adetola Adebayo Amballi, Hammed Adedeji Adenusi, Monisola Abosede Ayodele.

Abstract
Diabetes mellitus (DM) has become a disease of Global interest due to the variety of associated complications and economic implications. Scientific-based efforts are intensified on discovering economically friendly and non-toxic plant-based phytochemicals with efficient antihyperglycemic activities globally. This study assesses the antihyperglycemic and modifying potentials of aqueous Ocimum gratissimum leaf extract on histone deacetylases and cardiometabolic indices in streptozotocin-induced diabetes. Forty Wistar rats weighing 200-250g were selected randomly and induced for DM using 60mg/kg body weight streptozotocin administered intraperitoneally and dosed with the extract for 42 days. Fasting blood samples were collected daily from the tail vein of each rat and on day 42 for glucose, hepatorenal indices, lipid profile, malondialdehyde (MDA), total protein, albumin, urea, creatinine, bilirubin, aspartate amino transaminase (AST), alanine amino transaminase (ALT), alkaline phosphatase (ALP), and histone deacetylase (HDAC) activities determination. Plasma globulin, LDL, VLDL, atherogenic and coronary risk indices were computed. Weight changes were also monitored weekly. A 3%, 19.4%, 0.84%, 26.7%, and 1.3% weight decrease was observed in extract-treated (100 and 200 mg/kg), glibenclamide-treated, diabetic untreated, and normoglycemic groups, respectively. A significant increase (p<0.05) in plasma glucose, AST, ALT, ALP, total bilirubin, conjugated bilirubin, urea, creatinine, total cholesterol, triglyceride, LDL, AI, CRI, MDA, and HDAC activities; a significant decrease (p<0.05) in plasma HDL was observed in the diabetic untreated group. This study revealed that Ocimum gratissimum leaf exhibits antihyperglycemic and hypolipidemic properties; improves atherogenic risks and modifies HDAC activities in streptozotocin diabetes.

Key words: Ocimum gratissimum, histone deacetylases, antihyperglycemia, antilipidemia, streptozotocin

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How to Cite this Article

Pubmed Style

Soola JO, Olooto WE, Osonuga IO, Oyesola OA, Amballi AA, Adenusi HA, Ayodele MA. Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats. Equijost. 2024; 11(1): 74-80.

Web Style

Soola JO, Olooto WE, Osonuga IO, Oyesola OA, Amballi AA, Adenusi HA, Ayodele MA. Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats. https://www.equijost.com/?mno=187280 [Access: June 25, 2025].

AMA (American Medical Association) Style

Soola JO, Olooto WE, Osonuga IO, Oyesola OA, Amballi AA, Adenusi HA, Ayodele MA. Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats. Equijost. 2024; 11(1): 74-80.

Vancouver/ICMJE Style

Harvard Style

Soola, J. O., Olooto, . W. E., Osonuga, . I. O., Oyesola, . O. A., Amballi, . A. A., Adenusi, . H. A. & Ayodele, . M. A. (2024) Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats. Equijost, 11 (1), 74-80.

Turabian Style

Soola, Joseph Olugbenga, Wasiu Eniola Olooto, Ifabunmi Oduyemi Osonuga, Olusoji Adebusoye Oyesola, Adetola Adebayo Amballi, Hammed Adedeji Adenusi, and Monisola Abosede Ayodele. 2024. Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats. Equity Journal of Science and Technology, 11 (1), 74-80.

Chicago Style

Soola, Joseph Olugbenga, Wasiu Eniola Olooto, Ifabunmi Oduyemi Osonuga, Olusoji Adebusoye Oyesola, Adetola Adebayo Amballi, Hammed Adedeji Adenusi, and Monisola Abosede Ayodele. "Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats." Equity Journal of Science and Technology 11 (2024), 74-80.

MLA (The Modern Language Association) Style

Soola, Joseph Olugbenga, Wasiu Eniola Olooto, Ifabunmi Oduyemi Osonuga, Olusoji Adebusoye Oyesola, Adetola Adebayo Amballi, Hammed Adedeji Adenusi, and Monisola Abosede Ayodele. "Antihyperglycemic and cardiometabolic effects of ocimum gratissimum leaf extract in streptozotocin-induced diabetic rats." Equity Journal of Science and Technology 11.1 (2024), 74-80. Print.

APA (American Psychological Association) Style

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